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Primary hepatocytes isolated from mouse (Mus musculus) liver serve as a highly relevant in-vitro model that closely mimics the metabolic, detoxification, and biosynthetic functions of the intact liver. These parenchymal cells retain high metabolic activity and express functional Phase I & II drug-metabolizing enzymes (CYP3A, CYP2E1, CYP1A2), along with key biomarkers such as Albumin, HNF4α, and CK18.
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